Endocrine Abstracts

Objective: The aim of this study was to investigate sex-specific associations of two established serum selenium biomarkers, i.e. total selenium and selenoprotein P with type 2 diabetes mellitus (T2D) and hypertension in a large cohort of older people.Methods: 1500 participants with available selenium measurements from the Berlin Aging Study II (BASE-II) were included in this study. In the serum samples, spectroscopy was used to quantify total selenium, a...

Background: Mitotane,(o,p’-DDD)is a compound with potent adrenotoxic effect and is able to block cortisol synthesis by inhibiting 11β-hydroxylation and cholesterol chain cleavage. For these reasons, mitotane was widely used in the treatment of adrenocortical cancer. Nevertheless the biological mechanism induced by these treatments in this cancer cells remain unknown.Aim: To study whether the o,p’-DDD could increase the susceptibility to th...

Background. The endothelial dysfunction prevalent in hypertension and diabetes is associated with an imbalance in the levels of nitric oxide (NO) and superoxide (SO). NAD(P)H oxidase is the predominant source of SO in the vasculature. Objectives. To manipulate levels of SO using the NAD(P)H oxidase inhibitors, apocynin, phenyl arsine oxide (PAO) and 4(2aminoethyl)benzenesulfonyl fluoride (AEBSF) and relate this to NO bioavailability. Methods. NO bioavailability was compared in...

John S Bevan, Department of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK. AbstractJohn S Bevan is senior Consultant Endocrinologist at Aberdeen Royal Infirmary and Honorary Professor of Endocrinology at Aberdeen University. He qualified MB ChB, with Honours, from Edinburgh University in 1978 and his clinical training in Medicine & Endocrinology took place in Edinburgh, Oxford and Ca...

ObjectiveThyroid replacement therapy needs careful titration, and recently there has been discussion regarding the bioavailability of different thyroxine preparations [1]We have taken the opportunity of comparing thyroid function in 18 females who were enrolled in a trial studying the effects of thyroxine therapy on subclinical hypothyroidism [SCH].MethodsThese patients (at entry to tri...

Objectives: There is uncertainty about the best approach to management of type 1 diabetes (T1D) in clinically well children at diagnosis. This study, investigated the impact of home and hospital management on biopsychosocial and economic outcomes.Methods: Multi-centred randomised controlled trial. 203 newly diagnosed children aged 0–17 years from eight UK centres were randomised for treatment initiation at home (n=101) or in hospital (n...

Background: PAs are the most frequent pituitary neoplasms, however molecular pathogenesis is largely unknown. The AHR is a ligand-activated transcription factor that regulates expression of various genes that mediate cellular response to xenobiotics. The exact functional role of two AHR single nucleotide polymorphisms (SNPs); Arginine554Lysine (Arg554Lys) and Valine570Isoleucine (Val570Ile) has not yet been established, however studies suggest that these mutations might increa...

Gliomas are a highly heterogeneous group of brain tumours that are refractory to treatment, and highly invasive. The treatment and prognosis depend upon the tumor grade. Treatment of Grade II/III gliomas typically consists of maximal safe resection, followed by external beam radiation therapy. Although less aggressive than GBM, mortality is high with a 5-year survival rate of only 25.9%. Glioma tumors has been demonstrated NK-1 receptor system and substance P can be used as a ...

BackgroundAromatase deficiency is an extremely rare autosomal recessive condition due to mutations on CYP19A1 gene. Despite the size and complexity of this gene, only about 40 cases with aromatase deficiency have been reported.Case reportThe patient was born at term from non-consanguineous parents. Maternal signs of virilization were verified during third trimester (deep voice, acne on arms and face ...

Introduction: Paragangliomas belong to the neuroendocrine tumours arising from autonomic nervous system. Various localizations, symptoms that can mimic a wide range of diseases and often unpredictable ability to metastasize are the reasons why paragangliomas pose a significant diagnostic challenge. More than one third of paragangliomas is associated with germline mutations –succinate dehydrogenase (SDH) subunit genes are among the most common susceptibility genes. SDHD wa...